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> home > Products > Primary Antibodies > Antibody Collections > Head neck negative > Ephrin B2 Antibody
Ephrin B2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P52799 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | Efnb2; ephrin B2; EPLG5; Htk L; HTK ligand; HTK-L; HTKL; LERK5; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 36923 Da |
| Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Ephrin B2 |
| Description | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | EFNB2 |
|---|---|
| Synonyms | EPLG5, HTKL, LERK5 |
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800} |
| Tissue Location | Lung and kidney. |
Research Areas
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Application Protocols
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$ 195.00
$ 385.00
Cat# AP91533
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